abstract：:In a single-blind, placebo-controlled crossover trial, the acute efficacy of the dopamine agonist pramipexole was investigated in 11 restless legs syndrome (RLS) patients by sleep laboratory methods, with a clinical follow-up for 4 weeks. In 3 nights (pre-treatment, placebo and drug night), objective sleep quality was...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Saletu M,Anderer P,Saletu-Zyhlarz G,Hauer C,Saletu B

更新日期：2002-08-01 00:00:00

abstract：:Complaints of sleep disturbances are common among alcohol dependent patients during subacute abstinence. Recovered patients may show persistent sleep abnormalities for months or even years. In the present study we studied the issue whether periodic limb movements in sleep and disturbances of nocturnal respiration are ...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Gann H,Feige B,Fasihi S,van Calker D,Voderholzer U,Riemann D

更新日期：2002-06-01 00:00:00

abstract：:Savoxepine, an atypical neuroleptic compound developed in the 1980s, was believed to act via selective limbic dopamine D(2)-receptor blockade. The results of the presented double-blind, randomised, controlled clinical trial comparing savoxepine (n = 58) with haloperidol (n = 29) did not confirm the preclinical data su...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Volz HP,Möller HJ,Gerebtzoff A,Bischoff S

更新日期：2002-04-01 00:00:00

abstract：:Previous research on neuropsychological disturbances in first-episode and chronic schizophrenic patients has provided mixed results which can be partially attributed to methodological inconsistencies. For the present study, 70 schizophrenic patients (40 with chronic and 30 with first-episode schizophrenia) were compar...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Moritz S,Andresen B,Perro C,Schickel M,Krausz M,Naber D,PERSIST Study Group.

更新日期：2002-02-01 00:00:00

abstract：OBJECTIVE:The goal of this study was to identify adverse effects of the atypical neuroleptic clozapine on liver function and lipid metabolism. METHODS:Data which included serum levels of clozapine and its hepatic metabolite N-desmethyl clozapine were collected from medical records of patients treated with clozapine an...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Wiltfang J,Schenk-Daprá B,Stiens G,Bleich S,Bandelow B,Müller P,Niedmann PD,Armstrong VW,Rüther E

更新日期：2001-12-01 00:00:00

abstract：:In a previous publication we reported lifetime and 3-month prevalence estimates for substance use in two large samples of schizophrenic inpatients (Soyka et al. 1993). A subsequent analysis of psychopathological findings assessed by means of the AMDP Manual (Guy and Ban 1982) in schizophrenic in-patients of the Haar M...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Soyka M,Albus M,Immler B,Kathmann N,Hippius H

更新日期：2001-10-01 00:00:00

abstract：:Astrocytes are the most numerous cell type within the central nervous system. Early during development they act as guiding structures for migratory neurons; later they are not only the main source for nutrients and growth factors in the brain, but they are also communication partners of neighboring neurons. For this p...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Kirchhoff F,Dringen R,Giaume C

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND:Although a number of studies have reported on the association between obsessional personality features as measured by the Munich Personality Test (MPT) "Rigidity" scale and depression, there has been no examination of these relationships in a non-clinical sample. METHODS:The dimensional scores on the MPT we...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Sakado K,Sakado M,Seki T,Kuwabara H,Kojima M,Sato T,Someya T

更新日期：2001-06-01 00:00:00

abstract：:To improve recognition and treatment of depression in primary care it would be advantageous to have criteria for identification of later depression. Only a few studies were performed on primary care samples to examine risk factors for new depressive episodes. These were mostly cross-sectional and did not include psych...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Barkow K,Heun R,Ustün TB,Maier W

更新日期：2001-01-01 00:00:00

abstract：:The conceptualization of rapidly cycling bipolar disorder remains controversial. The DSM-IV definition of rapid cycling, although very reliable, may be not sufficiently inclusive (i.e., it may exclude patients with very short episodes of very high frequency, who are very typical in terms of external validators, and ar...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Maj M

更新日期：2001-01-01 00:00:00

abstract：:The present article outlines the different conception of catatonia from its initial description by Kahlbaum to current viewpoints. Originally considered to be an independent disease entity characterized by mental and motor abnormalities, catatonia was later viewed as a subtype of schizophrenia as it is the case in cur...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Pfuhlmann B,Stöber G

更新日期：2001-01-01 00:00:00

abstract：:Working memory and information processing abnormalities are often reported in schizophrenia. The aim of this study was to examine visual backward masking (BM) functions in remitted schizophrenia-spectrum patients with spared working memory functions. Seventy-two patients with DSM-IV schizophrenia-spectrum disorders we...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Kéri S,Szendi I,Kelemen O,Benedek G,Janka Z

更新日期：2001-01-01 00:00:00

abstract：:In clinical trials in psychiatry, changes in severity are usually measured with ordinal level scales which are applied repeatedly during the trial, showing a constant decline in psychopathology scores as treatment leads to improvement. Previous non-parametric tests for repeated measures in factorial designs did not te...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Bandelow B,Brunner E,Beinroth D,Pralle L,Broocks A,Hajak G,Rüther E

更新日期：1999-01-01 00:00:00

abstract：:Theoretical and empirical models of thought disorder (ThD) were tested through Confirmatory factor analysis (CFA). A sample of 253 DSM-III-R acute schizophrenic patients consecutively admitted was studied. A semistructured interview for schizophrenia was used for diagnosis, and ThD was assessed by means of the Thought...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Cuesta MJ,Peralta V

更新日期：1999-01-01 00:00:00

abstract：:The main goal of the present study was to explore whether regional cerebral blood flow (rCBF) differs between obsessive-compulsive disorder (OCD) patients without chronic motor tic disorder and those OCD patients with a comorbid chronic tic disorder. Twenty-seven patients suffering from OCD (DSM-IV criteria), includin...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Crespo-Facorro B,Cabranes JA,López-Ibor Alcocer MI,Payá B,Fernández Pérez C,Encinas M,Ayuso Mateos JL,López-Ibor JJ Jr

更新日期：1999-01-01 00:00:00

abstract：:An international, multicentre, double blind parallel group study compared the tolerability and efficacy of moclobemide with the selective serotonin reuptake inhibitor (SSRI) fluoxetine for panic disorder. SSRIs have been shown effective for panic. The target dose of moclobemide was 450 mg and of fluoxetine was 20 mg. ...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Tiller JW,Bouwer C,Behnke K

更新日期：1999-01-01 00:00:00

abstract：:Preventive endeavours in psychotic disorders have been hampered by many obstacles over the past century. One important barrier has been the corrosive pessimism which has attached to the treatment prospects for schizophrenia in particular since the time of Kraepelin, and the isolation of this disorder from progressive ...

journal_title：European archives of psychiatry and clinical neuroscience

authors： McGorry PD

更新日期：1998-01-01 00:00:00

abstract：:Mutations in the presenilin-1 gene (PS-1 gene) on chromosome 14 have recently been identified as a cause of familial early-onset Alzheimer's disease (EOAD). To our knowledge, only two German EOAD patients with mutations in the PS-1 gene have been identified thus far. Herein we report the case of a German EOAD patient ...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Hüll M,Fiebich BL,Dykierek P,Schmidtke K,Nitzsche E,Orszagh M,Deuschl G,Moser E,Schumacher M,Lücking C,Berger M,Bauer J

更新日期：1998-01-01 00:00:00

abstract：:The course of obsessive-compulsive disorder (OCD) is variable, ranging from episodic to chronic. We hypothesised that the former course is more likely to be related to bipolar mood disorders. With the use of a specially constructed OCD questionnaire, we studied 135 patients fulfilling DSM-III-R criteria for OCD with a...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Perugi G,Akiskal HS,Gemignani A,Pfanner C,Presta S,Milanfranchi A,Lensi P,Ravagli S,Maremmani I,Cassano GB

更新日期：1998-01-01 00:00:00

abstract：:The Anorexia Nervosa Inventory for Self-Rating (ANIS) was the first instrument covering aspects of the general psychopathology of eating disorders alongside eating attitudes, but its factorial integrity in non-clinical samples has not yet been investigated. Thus, this report is aimed at assessing the factorial structu...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Rathner G,Rainer B

更新日期：1998-01-01 00:00:00

abstract：:Event-related potentials (ERPs) can serve as markers for cognitive processing stages. Identification of those ERPs altered in schizophrenia offer information about cognitive dysfunction. Auditory evoked potentials (AEPs) were elicited within an oddball paradigm in 35 schizophrenic patients and compared with 35 healthy...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Frodl T,Meisenzahl EM,Gallinat J,Hegerl U,Möller HJ

更新日期：1998-01-01 00:00:00

abstract：:Knowledge on the reliability of family history information is essential for every family study. However, systematic analyses of interinformant reliability of family history information on individual relatives have not yet been published. Consequently, family history information on 1306 first-degree relatives and spous...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Heun R,Müller H

更新日期：1998-01-01 00:00:00

abstract：:This study concerns the validation of an instrument, the SAB2, designed to measure child behaviour and to help identify emotional problems which arise because the child has been a victim of child sexual abuse. Clinically disturbed children, mainstream school children and sexually abused youngsters were assessed. Relia...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Hildreth AJ,Place M

更新日期：1997-01-01 00:00:00

abstract：:The cytokines interleukin-2 (IL-2) and interleukin-6 (IL-6) increase during immune activation, they are released from activated astrocytes and microglial cells in the central nervous system (CNS), and they are able to enhance the catecholaminergic neurotransmission. This study focused on the soluble receptors of IL-2 ...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Müller N,Empl M,Riedel M,Schwarz M,Ackenheil M

更新日期：1997-01-01 00:00:00

abstract：:For the functional psychoses of late life, epidemiological information comes from two sources: studies of persons who have reached psychiatric services; and surveys of elderly persons sampled from the general population. A conspectus of published data from both sources leads to the following conclusions: States phenom...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Henderson AS,Kay DW

更新日期：1997-01-01 00:00:00

abstract：:As a result of the multifactorial etiopathology of schizophrenia, a treatment strategy combining drug therapy with psychosocial measures is indicated. Depending on the stage of the disease and on the individual condition of the patient, the accent is set alternatively more on one approach or on the other. However, und...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Möller HJ

更新日期：1996-01-01 00:00:00

abstract：:Although the Bonn Scale for the Assessment of Basic Symptoms (BSABS) [13] has come into use in several European countries, its diagnostic validity has not yet been sufficiently examined. That is why we have assessed BSABS items on a sample of 243 consecutive admissions to the Department of Psychiatry at the RWTH Unive...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Klosterkötter J,Ebel H,Schultze-Lutter F,Steinmeyer EM

更新日期：1996-01-01 00:00:00

abstract：:Family history and psychosocial background factors were studied in married patients with a DSM-III diagnosis of schizoaffective disorder (n = 17, partners n = 16), married patients with diabetes (n = 10, partners n = 10) and married healthy individuals (n = 8, partners n = 8). The two latter groups were comparison con...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Nettelbladt P,Svensson C,Serin U

更新日期：1996-01-01 00:00:00

abstract：:Reports on left-lateralized abnormalities of component P300 of event-related brain potentials (ERP) in schizophrenics typically did not vary task difficulties. We collected 16-channel ERP in 13 chronic, medicated schizophrenics (25 +/- 4.9 years) and 13 matched controls in a visual P300 paradigm with targets defined b...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Kochi K,Koenig T,Strik WK,Lehmann D

更新日期：1996-01-01 00:00:00

abstract：:Negative symptoms were examined in 150 primarily first-admission patients diagnosed with schizophrenia, schizoaffective disorder, psychotic depression, psychotic bipolar disorder, and 'other' psychoses. The analysis focused on patients who were rated on the Scale for the Assessment of Negative Symptoms (SANS) within 4...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Fennig S,Bromet EJ,Galambos N,Putnam K

更新日期：1996-01-01 00:00:00

abstract：:This paper reports on psychiatric case identification by the application of the Structured Clinical Interview for DSM-III-R (SCID) in a sample of 198 Greek migrants repatriated from western europe in a northwestern province of Greece. The current (1 month) prevalence of psychiatric morbidity, based on the total number...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Bilanakis N,Madianos MG,Liakos A

更新日期：1995-01-01 00:00:00

abstract：:The relationship between lateral ventricular size or its asymmetry and age at the onset of schizophrenia was investigated in 20 schizophrenic patients diagnosed according to DSM-III-R criteria. The ventricle-brain ratio (VBR) was determined using three transaxial slices of magnetic resonance image (MRI) and asymmetry ...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Aso M,Kurachi M,Suzuki M,Yuasa S,Matsui M,Saitoh O

更新日期：1995-01-01 00:00:00

abstract：:A summarised account is given of Emil Kraepelin's research in the field of mental disorder, underlining his emphasis on objectivity and natural science and the need for a multi-disciplinary approach. At the same time attention is drawn to the limitations of his general outlook and to his political views, which in thei...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Shepherd M

更新日期：1995-01-01 00:00:00

abstract：:Those who as adults will be admitted to a psychiatric ward with a psychotic illness can be distinguished (on the basis of group differences) from others by their behaviour and academic performance at the ages of 7 and 11 years. Pre-schizophrenic boys are anxious and hostile towards adults and peers at the age of 7 yea...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Crow TJ,Done DJ,Sacker A

更新日期：1995-01-01 00:00:00

abstract：:Two sisters with muscular dystrophy of Becker-like clinical features presented. Muscle weakness was most prominent in the pelvic girdle, but in the elder sister the distal muscles of the lower extremities were also affected. The progression was different in the siblings: The older sister showed a more pronounced deter...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Diószeghy P,Molnár M,Mechler F

更新日期：1995-01-01 00:00:00

abstract：:The effect of comorbidity on rates of suicidal ideation and suicide attempts from an adult general population of former West Germany is investigated. The assessment instrument is a modified German version of the Diagnostic Interview Schedule (DIS), a fully standardized interview for the assessment of selected DSM-III ...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Bronisch T,Wittchen HU

更新日期：1994-01-01 00:00:00

abstract：:Smooth-pursuit eye-tracking performance was examined in 100 schizophrenic patients and various control groups under both attention-enhancing and attention-distracting conditions. The level of attentional demand was varied by introducing a secondary reaction time task that directed attention either toward or away from ...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Schlenker R,Cohen R,Berg P,Hubman W,Mohr F,Watzl H,Werther P

更新日期：1994-01-01 00:00:00

abstract：:D1-dopamine receptor binding in the brain was determined by positron emission tomography (PET) in five patients with Huntington's disease, in one asymptomatic gene carrier and in five control subjects. [11C] SCH 23390 was used as the radioligand. Brain morphology was recorded by MRI. The patients who all had a mild to...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Sedvall G,Karlsson P,Lundin A,Anvret M,Suhara T,Halldin C,Farde L

更新日期：1994-01-01 00:00:00

abstract：:In the present study, quantitative EEG analysis was performed at rest and during 10 Hz photic stimulation in 14 drug-naive patients with first-episode paranoid schizophrenia and 20 sex- and age-matched control subjects. Compared with the normal controls, the patients had significantly lower alpha-2 band amplitude in t...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Wada Y,Takizawa Y,Kitazawa S,Jiang ZY,Yamaguchi N

更新日期：1994-01-01 00:00:00

abstract：:A group of 52 patients presenting at an outpatient unit for anxiety disorders were included consecutively in a prospective 2-year follow-up study. Patients were administered to a structured interview for DSM-III-R diagnoses, a follow-up interview (LIFE), and various other ratings. Sociodemographic and illness-history ...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Scheibe G,Albus M

更新日期：1994-01-01 00:00:00